Work

Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

Year: 2018

Type: article

Abstract: The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of "off-target" mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2018.1432259

Authors: Yunxiang Mu, Kevin M. McBride

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590