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Immunosuppression Withdrawal is an Effective Treatment of Relapse after Allogeneic Stem Cell Transplant for Myelofibrosis

Year: 2018
Type: article
Abstract: Allogeneic stem cell transplant (allo-SCT) is the only potential curative treatment for myelofibrosis (MF). However, relapse after transplant remains one of the leading causes of death. Treatment options for relapsed patients are very limited with no standardized approaches. Immunomodulation has been used in this context, but there is no evidence to date to support the use of immunosuppression reduction/withdrawal alone as primary treatment for mixed chimerism (MM) and/or relapsed MF after transplant.
DOI: 10.1016/j.bbmt.2017.12.155
Authors: Samer A. Srour, Parth Desai, Stefan O. Ciurea, Qaiser Bashir, Betul Oran, Amanda Olson, Sairah Ahmed, Prithviraj Bose, Rohtesh S. Mehta, Naveen Pemmaraju, Amin M. Alousi, Srdan Verstovsek, Richard E. Champlin, Uday R. Popat
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2790499742
FWCI:
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Cited by: 1
Related to: 10