Work

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Year: 2018

Type: review

Abstract: The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that range from direct assembly, encapsulation and composite formation. We will discuss factors that affect the efficacy of nanoassemblies for delivery from the perspective of both nanoparticles and proteins. Challenges in the field, particularly achieving effective cytosolar protein delivery through endosomal escape or evasion are discussed.

Source: Chemical Society Reviews

DOI: 10.1039/c8cs00008e

Authors: Federica Scaletti, Joseph Hardie, Yi-Wei Lee, David C. Luther, Moumita Ray, Vincent M. Rotello

Institutions: Amherst College, University of Massachusetts Amherst

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, NIH Office of the Director, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering