796: SEMA4F Overexpression in Perineural Invasion in Vitro Model of Prostate Cancer and Its Functional Involvement in Axonogenesis
Year: 2006
Type: article
Abstract: CONCLUSIONS: A low-carbohydrate diet resulted in a significant reduction in cancer growth, associated with decrease in serum insulin and IGF-1.Millions of men and women are on some form of a lowcarbohydrate, high-fat, diet.Evidence strongly implicates insulin and the IGF axis as critical determinants of many cancers.Although additional environmental and genetic factors are likely to affect PCa, the incidence of this disease was low before the advent of a sedentary life style, high-fat intake and/or obesity.During this period, there has been a significant increase in other factors such as the intake of highly processed carbohydrates.Well established interactions between dietary carbohydrates, insulin, the IGF family of proteins, and cancer mitogens, provide a plausible hypothesis that a low-carbohydrate, high-fat, diet in addition to its putative weight control properties may also abrogate the carcinogenic effects of the typical "Western" diet.If proven, this would likely modify the eating habits and may substantially reduce the rate of prostate and other cancers.
Source: The Journal of Urology
Authors: Hong Dai, Rile Li, Michael Ittmann, Thomas M. Wheeler, Gustavo Ayala
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2790768266