Work

Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Driver of Iclaprim

Year: 2018

Type: article

Abstract: ABSTRACT The neutropenic murine thigh infection model was used to define the pharmacokinetic/pharmacodynamic index linked to efficacy of iclaprim against Staphylococcus aureus ATCC 29213 and Staphylococcus pneumoniae ATCC 10813. The 24-h area under the curve (AUC)/MIC index was most closely linked to efficacy for S. aureus ( R 2 , 0.65), while both the 24-h AUC/MIC and the percentage of time that drug concentrations remain above the MIC (% T >MIC) were strongly associated with effect ( R 2 , 0.86 for both parameters) for S. pneumoniae .

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02550-17

Authors: Jee Hyun Park, William Craig, Karen Marchillo, David B. Huang, David R. Andes

Institutions: National Institutes of Health, National Cancer Institute, University of Wisconsin–Madison, Motif BioSciences (United States), Rutgers New Jersey Medical School

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2790850802

FWCI: 0.968

Cites: 8

Cited by: 8

Related to: 10