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Analysis of Single Nucleotide Polymorphisms (SNP) Donor/Recipient Mismatches in the Gamma Block of the Major Histocompatibility Complex (MHC) and Their Association with Hematopoietic Cell Transplantation (HCT) Outcomes: A CIBMTR Study

Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: HLA haplotype mismatches have been associated with higher risk of acute graft versus host disease (aGVHD) in patients receiving HLA matched MUD HCT. However, beyond the HLA-A, B, C, DRB1, DQB1 and DPB1 loci currently considered for matching in clinical HCT, the MHC contains > 400 genes that may encode for unidentified transplant antigens. The Gamma block (GB) is located in the central MHC region between beta and delta blocks (encoding C & B and DR & DQ antigens, respectively). GB contains many inflammatory and immune regulatory genes such as Bf, C2 and C4 genes.
DOI: 10.1016/j.bbmt.2017.12.426
Authors: Medhat Askar, David Sayer, Tao Wang, Michael Haagenson, Stephen R. Spellman, Stephanie J. Lee, Katharina Fleischhauer, Katharine C. Hsu, Michael R. Verneris, Dawn Thomas, Aiwen Zhang, Ronald M. Sobecks, Navneet S. Majhail
Institutions: Baylor University Medical Center, Medical College of Wisconsin, Fred Hutch Cancer Center, University of Duisburg-Essen, Memorial Sloan Kettering Cancer Center, University of Colorado Denver, Cleveland Clinic
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2790883862
FWCI: 0.18
Cites:
Cited by: 1
Related to: 10