Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy
Year: 2018
Type: article
Abstract: Key Points We established a Nudt15 knockout mouse model with which to evaluate individualized thiopurine therapy. Preemptive NUDT15 genotype–guided thiopurine dosing can effectively prevent drug toxicity without compromising antileukemic efficacy.
Source: Blood
Authors: Rina Nishii, Takaya Moriyama, Laura J. Janke, Wenjian Yang, Chase C. Suiter, Ting-Nien Lin, Lie Li, Kentaro Kihira, Hidemi Toyoda, Ute Hofmann, Matthias Schwab, Masatoshi Takagi, Tomohiro Morio, Atsushi Manabe, Shirley Kham, Nan Jiang, Karen R. Rabin, Motohiro Kato, Katsuyoshi Koh, Allen Eng-Juh Yeoh, Hiroki Hori, Jun J. Yang
Institutions: Tokyo Medical and Dental University, St. Jude Children's Research Hospital, Mie University, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Universitätsklinikum Tübingen, St. Luke's International Hospital, National University of Singapore, Khoo Teck Puat Hospital, National University Hospital, National University Health System, Baylor College of Medicine, National Center For Child Health and Development, Saitama Children's Medical Center, Cancer Science Institute of Singapore
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2791017116