Untargeted Metabolomics Reveals Multiple Metabolites influencing Smoking-Related DNA Methylation
Year: 2018
Type: article
Study design: Observational Study
Abstract: AIM: We conducted a joint metabolomic-epigenomic study to identify patterns of epigenetic associations with smoking-related metabolites. PATIENTS & METHODS: We performed an untargeted metabolome-wide association study of smoking and epigenome-wide association studies of smoking-related metabolites among 180 male twins. We examined the patterns of epigenetic association linked to smoking-related metabolites using hierarchical clustering. RESULTS: Among 12 annotated smoking-related metabolites identified from a metabolome-wide association study, we observed significant hypomethylation associated with increased level of N-acetylpyrrolidine, cotinine, 5-hydroxycotinine and nicotine and hypermethylation associated with increased level of 8-oxoguanine. Hierarchical clustering revealed common and unique epigenetic-metabolic associations related to smoking. CONCLUSION: Our study suggested that a joint metabolome-epigenome approach can reveal additional details in molecular responses to the environmental exposure to understand disease risk.
Source: Epigenomics
Institutions: Emory University, University of Washington
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, American Heart Association, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Nursing Research, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Center for Research Resources
Awards: G1250529995, Mechanisms Linking Depression to Cardiovascular Risk, Neural Circuits in Women with Abuse and PTSD, Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure, Posttraumatic Stress Disorder and Cardiovascular Disease, Biological Correlates of Traumatic Stress, Identification of genetic and metabolomic markers influencing dystonia, G5921946093, Mind-Body Interactions in Cardiovascular Disease, GENERAL CLINICAL RESEARCH CENTER, Mechanisms of Depression in CVD, HERCULES: Exposome Research Center, IRACDA Fellowships in Research and Science Training (FIRST)
OpenAlex ID: W2791115778