Greater Neonatal Fat‐Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain
Year: 2018
Type: article
Study design: Clinical Trial
Abstract: OBJECTIVE: The objective of this study was to determine the effectiveness of controlling maternal gestational weight gain (GWG) in the second and third trimesters on neonate body composition. METHODS: Two hundred ten healthy women with overweight (25 > BMI < 30) or obesity (BMI ≥ 30) were randomly assigned to a lifestyle intervention (LI) program focused on controlling GWG through nutrition and activity behaviors or to usual obstetrical care (UC). Infant fat and fat-free mass (FFM) at birth were measured by using air displacement plethysmography (PEA POD) and by using quantitative magnetic resonance (QMR). RESULTS: At baseline, there were no between-group differences in maternal characteristics (mean [SD]): age: 33.8 (4.3) years, weight: 81.9 (13.7) kg, BMI: 30.4 (4.5), and gestational age at randomization: 14.9 (0.8) weeks. GWG was less in the LI group by 1.79 kg (P = 0.003) or 0.0501 kg/wk (P = 0.002). Compared with UC infants, LI infants had greater weight (131 ± 59 g P = 0.03), FFM (98 ± 45 g; P = 0.03) measured by PEA POD, and lean mass (105 ± 38 g; P = 0.006) measured by QMR. Fat mass and percent fat were not significantly different. CONCLUSIONS: Intervening in women with overweight and obesity through behaviors promoting healthy diet and physical activity to control GWG resulted in neonates with similar fat and greater FFM.
Source: Obesity
DOI: 10.1002/oby.22079
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: George Washington University, National Institutes of Health, Indian Health Service, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, National Center for Complementary and Integrative Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium, G5447144095, Preventing excessive gestational weight gain in obese women, Pregnancy and EARly Lifestyle improvement Study (PEARLS), G645702072, Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT), Weight Management in Obese Pregnant Underserved African American Women, G7153522333, Expecting Success: Personalized management of body weight during pregnancy, Lifestyle Interventions in Overweight and Obese Pregnant Women, G9000090439, New York Obesity Research Center, Obesity Research Center Training Grant
OpenAlex ID: W2791316112