Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
Year: 2018
Type: article
Study design: Observational Study
Abstract: AIMS/HYPOTHESIS: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. METHODS: We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution. RESULTS: range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined. CONCLUSIONS/INTERPRETATION: Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.
Source: Diabetologia
Authors: Sherly X. Li, Fumiaki Imamura, Matthias B. Schulze, Jusheng Zheng, Zheng Ye, Antonio Agudo, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Sara Grioni, Marc J. Gunter, José María Huerta, Daniel B. Ibsen, Marianne Uhre Jakobsen, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Cecilie Kyrø, Francesca Romana Mancini, Elena Molina-Portillo, Neil Murphy, Peter M. Nilsson, N. Charlotte Onland-Moret, Domenico Palli, Salvatore Panico, Alaitz Poveda, J. Ramón Quirós, Fulvio Ricceri, Ivonne Sluijs, Annemieke M. W. Spijkerman, Anne Tjonneland, Rosario Tumino, Anna Winkvist, Claudia Langenberg, Stephen J. Sharp, Elio Riboli, Robert A. Scott, Nita G. Forouhi, Nicholas J. Wareham
Institutions: University of Cambridge, MRC Epidemiology Unit, German Center for Diabetes Research, German Institute of Human Nutrition, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Oslo Nye Høyskole, Imperial College London, Basque Government, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations, Fondazione IRCCS Istituto Nazionale dei Tumori, Centre international de recherche sur le cancer, Instituto Murciano de Investigación Biosanitaria, Aarhus University, Technical University of Denmark, German Cancer Research Center, University of Oxford, Danish Cancer Society, Universidad de Granada, Andalusian School of Public Health, Lund University, University Medical Center Utrecht, Istituto per lo Studio e la Prevenzione Oncologica, Federico II University Hospital, University of Naples Federico II, Skåne University Hospital, Umeå University, Gobierno del Principado de Asturias, University of Turin, National Institute for Public Health and the Environment, Associazione Iblea per la Ricerca Epidemiologica E.T.S., University of Gothenburg
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,490
Funders: World Health Organization, Compagnia di San Paolo, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, European Commission, Commonwealth Scholarship Commission, Bundesministerium für Bildung und Forschung, Cambridge University Hospitals, Cambridge Trust, Universitair Medisch Centrum Utrecht, Vetenskapsrådet, Deutsche Krebshilfe, Sixth Framework Programme, Medical Research Council, World Cancer Research Fund, Agentschap NL
Awards: G1075599542, Aetiology of type 2 diabetes and related metabolic disorders, Nutritional epidemiology, G1192877484, G1547781643, G2409987178, G263035233, G2742323354, G275550512, G2764226595, G2826529823, G2892497062, G299057155, G3216658785, G370598735, G3811008989, G382879149, G4145331238, Health of vegetarians, G4990591557, G515689015, G5787426001, G6085534252, G6206044308, G6442500046, G6594529311, G6641991021, G6723261869, G6820515600, G6957823285, G8102615189, G8361061312, NIHR Senior Investigator Award, G8585681489, NIHR Senior Investigator Award, G8846336397, G892496435, G8944598329, G8959392569, G899966268
OpenAlex ID: W2791531453