Work

Rad GTPase Deletion Attenuates Post-Ischemic Cardiac Dysfunction and Remodeling

Year: 2018

Type: article

Abstract: , hence to govern contractility. Reducing Rad levels increases cardiac output. Ablation of Rad also attenuated the inflammatory response following acute myocardial infarction (AMI). Future studies to target deletion of Rad in the heart could be conducted to establish a novel treatment paradigm whereby pathologically stressed hearts would be given a safe, stable positive inotropic support without arrhythmias and without pathological structural remodeling. Future investigations will also focus on establishing inhibitors of Rad, and testing the efficacy of Rad-deletion in cardioprotection relative to the time of onset of AMI.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2017.09.004

Authors: Janet R. Manning, Lakshman Chelvarajan, Bryana M. Levitan, Catherine N. Withers, Prabhakara R. Nagareddy, Christopher M. Haggerty, Brandon K. Fornwalt, Erhe Gao, Himi Tripathi, Ahmed Abdel-Latif, Douglas A. Andres, Jonathan Satin

Institutions: University of Kentucky, University of Alabama at Birmingham, Temple University

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,750

Funders: American Heart Association, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: Prevention of heart failure and remodeling through calcium channel modulation, Center of Research on Obesity and Cardiovascular Diseases, G363002690, Regulation of Calcium Channel Function by the Rem GTPase, Monomeric G-proteins and Cardioprotection from Heart Failure, Role of Bioactive Lipids in Stem Cell Mobilization and Homing in Cardiac Ischemia, Monomeric G-proteins and Cardioprotection from Heart Failure, Mechanisms of Long-term Cardiac Ion Channel Regulation

OpenAlex ID: W2791707705

FWCI: 0.567

Cites: 41

Cited by: 9

Related to: 10