Year: 2018
Type: article
Abstract: In colorectal cancer (CRC) cells, mutant Kirsten rat sarcoma (KRAS) cell-autonomously imparts Warburg-like1 metabolic changes through induction of Glucose transporter 1 (GLUT-1) (SLC2A1).2,3 We previously reported that mutant KRAS has marked effects on the constituents of CRC exosomes, including proteins and enzymes involved in metabolism and glycolysis.4,5 The present studies were designed to test whether mutant KRAS exosomes can alter the metabolic state cell-nonautonomously in recipient colonic epithelial cells.
Authors: Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Michelle Demory Beckler, Emily J. Poulin, Alex J. Walsh, Melissa C. Skala, Eliot T. McKinley, H. Charles Manning, Matthew R. Hight, Michael L. Schulte, Kimberly R. Watt, G. Daniel Ayers, Melissa M. Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Jeffrey L. Franklin, Robert J. Coffey
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,430
Awards: G1300984159, Radiochemistry Equipment for Molecular Imaging Tracer Production, G1489350012, G1607991872, G292747457, Radiofluorination Equipment for PET Imaging Research, SPORE in GI Cancer, G725763919, G7642566612, Role of EGFR ligand-containing exosomes in colorectal cancer, Molecular and Cellular Basis for Digestive Diseases, Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation
OpenAlex ID: W2791875411