Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth
Year: 2018
Type: article
Abstract: Objective To evaluate the association of magnesium sulfate (MgSO4) exposure and candidate gene polymorphisms with adverse neurodevelopmental outcomes following preterm birth. Study Design We performed a nested case–control analysis of a randomized trial of maternal MgSO4 before anticipated preterm birth for the prevention of cerebral palsy (CP). Cases were children who died within 1 year of life or were survivors with abnormal neurodevelopment at age 2 years. Controls were race- and sex-matched survivors with normal neurodevelopment. We analyzed 45 candidate gene polymorphisms in inflammation, coagulation, and vascular regulation pathways and their association with (1) psychomotor delay, (2) mental delay, (3) CP, and (4) combined outcome of death/CP. Logistic regression analyses, conditional on maternal race and child sex, and adjusted for treatment group, gestational age at birth and maternal education, were performed. Results Four hundred and six subjects, 211 cases and 195 controls, were analyzed. The strongest association was for IL6R (rs 4601580) in which each additional copy of the minor allele was associated with an increased risk of psychomotor delay (adjusted odds ratio 3.3; 95% confidence interval, 1.7–6.5; p < 0.001). Conclusion Candidate gene polymorphisms are associated with death and adverse neurodevelopmental outcomes following preterm birth. MgSO4 may abrogate this genotype association for some loci.
Source: American Journal of Perinatology
Authors: Steven Weiner, Dwight Rouse, Brian Mercer, Uma Reddy, Jay Iams, Ronald Wapner, Yoram Sorokin, Fergal Malone, Mary O'Sullivan, Alan Peaceman, Gary Hankins, Donald Dudley, Steve Caritis, Erin Clark, for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
Institutions: George Washington University, University of Alabama at Birmingham, MetroHealth, University of Tennessee Health Science Center, MetroHealth Medical Center, Case Western Reserve University, Eunice Kennedy Shriver National Institute of Child Health and Human Development, The Ohio State University, Thomas Jefferson University, Drexel University, Wayne State University, Columbia University, University of Miami, Northwestern University, The University of Texas Medical Branch at Galveston, The University of Texas at San Antonio Health Science Center, University of Pittsburgh, University of Utah
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: General Clinical Research Center, Maternal Fetal Medicine Network: Data Coordinating Cent*, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network, NICHD Maternal Fetal Medicine Units Network, NICHD Maternal-Fetal Medicine Units (MFMU) Network, Genetic Polymorphisms Associated with Cerebral Palsy and Neurodevelopmental Delay, Maternal-Fetal Medicine Units Network, NICHD Maternal Fetal Medicine Units Network, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Cooperative Multicenter Maternal Fetal Medicine Units Networks, Adverse Outcomes in Nulliparous Pregnancies: The Ohio Collaborative, Co-Operative Multicenter Trials in Obstetrics & Maternal Fetal Medicine, Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research Net, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, Multicenter Network of Maternal Fetal Medicine Units, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, Maternal Fetal Medicine Network, NICHD NETWORKS: DATA COORDINATING CENTER, NICHD Materal Fetal Medicine Units Network, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network - Northwestern Study Center, Maternal-Fetal Medicine Units (MFMU) Network, Case Western Reserve University Center of the NICHD MFMU Network, Columbia University Maternal-Fetal Medicine Units Network Clinical Center, NICHD maternal fetal medicine units network, UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies, Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1), Center for Environmental Health in Northern Manhattan
OpenAlex ID: W2791959607