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Nrf2 is a Critical Mediator of CD4 T Cell-Induced Acute Graft-Versus-Host Disease

Year: 2018
Type: article
Abstract: Nuclear factor erythroid-derived 2-like 2 (Nrf2) is an ubiquitously expressed transcription factor known as the master regulator of cellular redox state, but little is known about its role in T-cell biology. Here, we evaluated the impact of Nrf2 inhibition on alloreactive T (allo-T) cells in the context of an allogeneic hematopoietic cell transplant (allo-HCT).
DOI: 10.1016/j.bbmt.2017.12.126
Authors: Jennifer J. Tsai, Enrico Velardi, Yusuke Shono, Kimon Argyropoulos, Odette M. Smith, Amina Lazrak, Chen Liu, George F. Murphy, Ya-Yuan Fu, Alan M. Hanash, Robert R. Jenq, Jarrod A. Dudakov, Marcel R.M. van den Brink
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2792128771
FWCI:
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