Year: 2018
Type: article
Abstract: Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The two cancers have similar patterns of mutation and show no evidence of exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors have copy number gains and are present on extrachromosomal double minutes. Drug screening indicates causative roles for receptor tyrosine kinases and sensitivity to inhibitors of DNA repair. Y chromosome loss from a male clone infecting a female host suggests immunoediting. These results imply that Tasmanian devils may have inherent susceptibility to transmissible cancers and present a suite of therapeutic compounds for use in conservation.
Source: Cancer Cell
Authors: Maximilian R. Stammnitz, Tim H.H. Coorens, Kevin C. Gori, Dane Hayes, Beiyuan Fu, Jinhong Wang, Daniel E. Martin-Herranz, Ludmil B. Alexandrov, Adrian Baez-Ortega, Syd Barthorpe, Alexandra Beck, Francesca Giordano, Graeme W. Knowles, Young Mi Kwon, George Hall, Stacey Price, Ruth J. Pye, Jose M.C. Tubio, Hannah V.T. Siddle, Sukhwinder Singh Sohal, Gregory M. Woods, Ultan McDermott, Fengtang Yang, Mathew J. Garnett, Zemin Ning, Elizabeth P. Murchison
Language: English
Topic: Veterinary Oncology Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,883
Awards: G1391515613, G1417716424, G1789614835, G2229400760, G2421963375, G2841170398, G317962989, G322578443, G3696888736, G383669879, G4221547432, G4588668047, G4612446324, G4728032643, G4748000019, G500873356, G5447876543, G5686323013, Cominatorial therapeutics to target the cancer geneome., Genome diversity and evolution in transmissible cancers in dogs and tasmanian devils, G6153970391, Emergence, transmission and evolution of Tasmanian devil facial tumor disease, G7506201745, G7642076992, G7876076502, G7911662, G7942926491, G8403407359, G8582880963, G8683076984, G9000085753
OpenAlex ID: W2792314520