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Lymphopenia is associated with late onset Pneumocystis jirovecii pneumonia in solid organ transplantation

Year: 2018

Type: article

Abstract: Background Pneumocystis jirovecii pneumonia ( PJ P) affected 5%‐15% of solid organ transplant ( SOT ) recipients prior to universal prophylaxis, classically with trimethoprim‐sulfamethoxazole ( TMP ‐ SMX ). Guidelines generally recommend 6‐12 months of prophylaxis post‐ SOT , yet optimal duration and robust PJ P risk stratification have not been established. Methods A retrospective, single‐center, case‐control study of PJ P among SOT recipients from January 1998 to December 2013 was conducted. Cases had positive PJ direct fluorescent antibody assay of respiratory specimens. Controls were matched 4:1 by nearest date of SOT . Univariate testing and multivariate logistic regressions were performed. Results Fifteen cases were identified among 5505 SOT recipients (0.27% rate) and analyzed vs 60 controls. PJ P occurred on average 6.1 years (range 0.9‐13.8) post‐ SOT ; no case was receiving PJ P prophylaxis at diagnosis. Most were treated with reduced immunosuppression and TMP ‐ SMX plus steroids (80%). Six patients (40%) required critical care; 3 (20%) died. There were no significant demographic differences, though cases tended to be older at SOT (54 vs 48 years, P = .1). In univariate analysis, prior viral infection was more common among cases (67% vs 37%, P = .08). Lower absolute lymphocyte count ( ALC ) at diagnosis date was strongly associated with PJ P (400 vs 1230 × 10 6 cells/μL, P < .001); odds of infection were high with ALC ≤ 500 × 10 6 cells ( OR 18.7, P < .01). Conclusion Pneumocystis jirovecii pneumonia is a rare, late complication of SOT with significant morbidity and mortality. Severe lymphopenia may be useful in identifying SOT recipients who warrant continued or reinstated PJ P prophylaxis.

Source: Transplant Infectious Disease

DOI: 10.1111/tid.12876

Authors: W.A. Werbel, M.G. Ison, M.P. Angarone, A. Yang, V. Stosor

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Northwestern University

Language: English

Topic: Pneumocystis jirovecii pneumonia detection and treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Advancing Translational Sciences