see related Editorial on page 803: Family History of Colorectal Cancer in First-Degree Relatives and Metachronous Colorectal Adenoma
Year: 2018
Type: article
Abstract: OBJECTIVES: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. METHODS: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. RESULTS: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05-1.53) or sibling (OR = 1.34; 95% CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. CONCLUSIONS: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.
Institutions: University of North Carolina at Chapel Hill, National Institutes of Health, University of Arizona, Oregon Health & Science University, University of California San Diego, National Cancer Institute, University of Arizona Cancer Center, Imperial College London, VA San Diego Healthcare System, Moores Cancer Center, Portland VA Medical Center, Division of Cancer Epidemiology and Genetics
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Advanced Colorectal Neoplasia Following Polypectomy, G2012428765, G2159449340, G219746026, G2339104728, G247295269, G2620658983, Optimizing Colorectal Cancer and Polyp Surveillance after Colorectal Polypectomy, G3558230680, G3559709381, G385835697, G4237449534, G4291216142, G517873728, Aspirin/Folate Prevention of Large Bowel Polyps, G7117342392, Factores relacionados con la calidad de la colonoscopia en la práctica clínica, Colon Cancer Prevention Program Project Grant, Specialized Program Research Excellence (SPORE) in Gastrointestinal Cancer, Cancer Center Support Grant, University of Arizona Cancer Center - Cancer Center Support Grant
OpenAlex ID: W2792429013