445: Prostate Cancer Mortality After Radical Prostatectomy or Radiation Therapy in Men with Clinically Localized Prostate Cancer
Year: 2004
Type: conference-abstract
Abstract: INTRODUCTION AND OBJECTIVE: This study was to review prostate cancer specific mortality in men with localized disease and received radical prostatectomy (RP) or radiation therapy (XRT) in PSA-era.Furthermore, prognostic factors affecting the mortality were analyzed.METHODS: Out of 13,564 patients diagnosed with prostate cancer from 1988 to 2002 in the Department of Defense Center for Prostate Disease Research (DoD-CPDR) Multicenter Database, 4701 RP patients and 2731 XRT patients with post-treatment follow-up longer than 6 months were retrieved.For PSA recurrence-free survival estimation, PSA >0.2 ng/ml was used for RP patients and ASTRO criteria was used for XRT patients.Clinical metastases were identified via both nuclear imaging studies (bone scans) and radiographic studies (computed tomography, magnetic resonance imaging, etc.).Death causes were obtained from the patients' death certificates.The data was analyzed with Kaplan-Meier and multivariate Cox regression method.RESULTS: The median age at RP and XRT was 63.1 and 70.3 years, respectively.174 (3 .7%)RP patients and 228 (8.3%) RT patients developed clinical metastatic disease with an average of 5.1 and 4.5 years between treatment and clinical metastases.Among 382 (8.1%) RP death cases, 56 (14.7%) men died of prostate cancer.Of 725 (26.5%)XRT death cases, 134 (18.5%) men died of prostate cancer.The average survival time for RP and XRT patients were 6.2 and 5.5 years.The 5-year and 10-year overall survival rate were 94% and 72% after radical prostatectomy and 88% and 63 % after radiation therapy, respectively (p<0.05).Multivariate Cox analysis showed that race, diagnosis Gleason sum and PSA doubling time were independent predictors for prostate-specific mortality (p < 0.05), while diagnosis age, pretreatment PSA, clinical stage, and ratio of cancer positive biopsy cores over total biopsy cores were not.CONCLUSIONS: Diagnosis Gleason score, race and PSA doubling time are independent variables to predict prostate cancer specific death for the men in both groups.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2792567495