Work

A Retrospective Review of Fluconazole as Antifungal Prophylaxis in the Adult and Pediatric Haploidentical Stem Cell Transplant Population

Year: 2018

Type: article

Abstract: Background: Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients, affecting 3-10% in the first year, with a mortality rate of 30-50%. Haploidentical (Haplo) transplant is an independent risk factor for development of IFI, likely due to delayed immune reconstitution from T cell depletion techniques (such as post-transplant cyclophosphamide). Antifungal prophylaxis in this population remains poorly defined and variable.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2017.12.495

Authors: Andrew Rettew, Ali McBride, Faiz Anwer, Keri Renee Maher

Institutions: University of Arizona, Barnes-Jewish Hospital

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650