Work

The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events

Year: 2018

Type: article

Abstract: Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.

Source: Frontiers in Bioengineering and Biotechnology

DOI: 10.3389/fbioe.2018.00008

Authors: Yang Zhao, William Dunker, Yi-Tao Yu, John Karijolich

Institutions: Vanderbilt University, University of Rochester Medicine, University of Rochester, Vanderbilt-Ingram Cancer Center

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,801

Funders: Vanderbilt University, Vanderbilt University Medical Center, National Institutes of Health, National Institute of General Medical Sciences