Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study
Year: 2018
Type: article
Study design: Observational Study
Abstract: Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.
Source: International Journal of Cancer
DOI: 10.1002/ijc.31367
Authors: Sabine Naudin, Kuanrong Li, Tristan Jaouen, Nada Assi, Cecilie Kyrø, Anne Tjønneland, Kim Overvad, Marie‐Christine Boutron‐Ruault, Vinciane Rebours, Anne‐Laure Védié, Heiner Boeing, Rudolf Kaaks, Verena Katzke, Christina Bamia, Androniki Naska, Antonia Trichopoulou, Franco Berrino, Giovanna Tagliabue, Domenico Palli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Petra H. Peeters, H. B(as) Bueno‐de‐Mesquita, Elisabete Weiderpass, Inger Torhild Gram, Guri Skeie, Maria‐Dolores Chirlaque, Miguel Rodríguez‐Barranco, Aurelio Barricarte, Jose Ramón Quirós, Miren Dorronsoro, Ingegerd Johansson, Malin Sund, Hanna Sternby, Kathryn E. Bradbury, Nick Wareham, Elio Riboli, Marc Gunter, Paul Brennan, Eric J. Duell, Pietro Ferrari
Institutions: Centre international de recherche sur le cancer, Danish Cancer Society, Aarhus University, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Hôpital Beaujon, Centre de Recherche sur l'Inflammation, German Institute of Human Nutrition, German Cancer Research Center, National and Kapodistrian University of Athens, Hellenic Health Foundation, Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto per lo Studio e la Prevenzione Oncologica, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, Imperial College London, University of Malaya, National Institute for Public Health and the Environment, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Instituto Murciano de Investigación Biosanitaria, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Murcia, Universidad de Granada, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Gobierno del Principado de Asturias, Basque Government, Umeå University, Lund University, University of Oxford, University of Cambridge, MRC Epidemiology Unit, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, National Research Council Sri Lanka, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Food Standards Agency, Stroke Association, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Stavros Niarchos Foundation, Deutsche Krebshilfe, Université Claude Bernard Lyon 1, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Ministry of Health and Social Solidarity, Greece, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
Awards: G1075502044, G1090603134, G1192877484, G1241080153, G1265254713, G1288624241, G1344656563, G1504351974, G172151099, G1767199718, G1788645866, G1952936224, G1993546569, G2131326840, G2149865848, G2216207056, G2235605558, G2257231888, G2372467518, G2409987178, G2539064604, G2572521044, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G3010599472, G3049845011, G3077395769, G3170664214, G3189789075, G3212900607, G3216658785, G3452641779, G3461390129, G3544161537, G3675143906, G3747421453, G375319704, G3816092139, G382879149, G3980646122, G4015156572, G4041385912, G4049848471, G4081633361, G4213141252, G423622538, G4303038735, G43956866, G4473162978, Health of vegetarians, G459595259, G4682079261, G4811780622, G4818043738, G490534113, G5047213743, G5406065712, G558017500, G5706284561, G5868006920, G5897142711, G5990830295, G6085534252, G640002926, G6442500046, G6723261869, G6820515600, G6957823285, G7025202487, G7306252069, G7426181285, G7447125227, G7600088736, G7624991799, G7636244323, G7646326732, G7939399614, G8012318887, G8054841944, G8279237360, G8407261631, NIHR Senior Investigator Award, G8525262851, NIHR Senior Investigator Award, G876765158, G8978728421
OpenAlex ID: W2793176394