Work

EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy

Year: 2018

Type: article

Abstract: In recent work we identified Exonuclease 3'-5' domain-containing protein 2 (EXD2) as an RNase required for efficient mitochondrial translation. Here I describe in brief the cellular phenotypes caused by EXD2 deficiency and make the case that EXD2 inhibitors could be valuable agents for cancer therapy.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2018.1445943

Author: Travis H. Stracker

Institutions: Institute for Research in Biomedicine, Barcelona Institute of Science and Technology

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Centres de Recerca de Catalunya, Ministerio de Economía y Competitividad