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Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia

Year: 2018

Type: article

Abstract: Introduction: The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia.Material and methods: Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled.Flow-mediated dilation was assessed at baseline, and after 1 year's follow-up the incidence of hypertension was compared between those with and without hyperuricemia.The predictive value of baseline FMD for incident hypertension among hyperuricemia patients was evaluated.Results: A total of 222 participants were included.Mean systolic and diastolic blood pressure (BP) was 129.5 ±8.4 mm Hg and 78.3 ±7.9 mm Hg.Mean serum uric acid (UA) level was 4.4 ±2.8 mg/dl.Mean FMD was 5.1 ±2.7%.Compared to normal UA group, hyperuricemia group had higher proportion of male (58.4% vs. 61.2%),higher systolic BP (125.4 ±7.9 mm Hg vs. 132.1 ±7.3 mm Hg), serum high sensitivity C-reactive protein (3.9 ±2.2 mg/dl vs. 4.5 ±3.0 mg/dl) and UA (3.5 ±1.4 mg/dl vs. 5.7 ±0.7 mg/dl) levels, but lower mean FMD (5.6 ±2.4% vs. 4.8 ±2.0%) (p < 0.05 for all comparisons).No participant in normal UA group developed hypertension, while in hyperuricemia group, 6 participants developed hypertension.In hyperuricemia participants, after adjusted for covariates, per 1-standard deviation decrease in baseline FMD remained significantly associated with 15% increased risk of incident hypertension.Conclusions: Patients with hyperuricemia have an increased risk of developing hypertension, and low baseline FMD in hyperuricemia patients is associated with significantly increased risk of incident hypertension.

Source: Archives of Medical Science

DOI: 10.5114/aoms.2018.73856