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Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

Year: 2018
Type: article
Study design: Clinical Trial
Abstract: The effect of treatment with histone deacetylase inhibitors on the immune system in HIV-infected individuals is not clear. Analysis of results from a clinical trial in which 15 HIV-infected individuals received 12 doses of panobinostat identified a significant impact on both T cell activation status and regulatory T cell suppressive marker expression and a reduced level of monocytic responsiveness to inflammatory stimuli. These changes were substantiated by global gene expression analysis. Collectively, the results suggest that panobinostat has multiple effects on innate and adaptive immune responses. Importantly, all the effects were transient, and further panobinostat treatment did not cause persistent long-term changes in gene expression patterns in HIV-infected individuals.
Source: mSphere
DOI: 10.1128/msphere.00616-17
Authors: Christel Rothe Brinkmann, Jesper Falkesgaard Højen, Thomas Aagaard Rasmussen, Anne Sofie Kjær, Rikke Olesen, Paul W. Denton, Lars Østergaard, Zhengyu Ouyang, Mathias Lichterfeld, Xu Yu, Ole Schmeltz Søgaard, Charles Dinarello, Martin Tolstrup
Institutions: Aarhus University Hospital, Aarhus University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, Radboud University Medical Center, University of Colorado Denver
Language: English
Subfield: Virology
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W2793373971
FWCI: 1.964
Cites: 45
Cited by: 22
Related to: 10