Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut
Year: 2018
Type: review
Abstract: The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.
DOI: 10.1002/jpen.1121
Institutions: Cardinal Glennon Children’s Medical Center, Saint Louis University, University College Dublin, Virginia Commonwealth University, Brigham and Women's Hospital, Harvard University, Purdue University West Lafayette, Columbia University Irving Medical Center, Columbia University, Baylor College of Medicine, Texas Children's Hospital, Mayo Clinic, Mayo Clinic Hospital, Oregon Health & Science University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2793471017