Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive‐mechanical‐loading porcine cutaneous wounds

Year: 2018

Type: article

Abstract: Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule-fibromodulin (FMOD) protein-can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD-based technologies hold high translational potential and applicability to human patients suffering from scarring-especially hypertrophic scarring.

Source: Journal of Cellular and Molecular Medicine

DOI: 10.1111/jcmm.13516

Authors: Wenlu Jiang, Kang Ting, Soonchul Lee, Janette N. Zara, Richard Song, Chenshuang Li, Eric Chen, Xinli Zhang, Zhihe Zhao, Chia Soo, Zhong Zheng

Institutions: University of California, Los Angeles, Sichuan University, State Key Laboratory of Oral Diseases, CHA University Bundang Medical Center, CHA University, Orthopaedic Hospital

Language: English

Topic: Dermatologic Treatments and Research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,210

Funders: National Science Foundation, Plastic Surgery Foundation, National Institutes of Health, University of California, Los Angeles, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research, National Center for Research Resources, Division of Chemistry, California NanoSystems Institute

OpenAlex ID: W2793474366