Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates
Year: 2018
Type: article
Abstract: In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
Source: Nanoscale
DOI: 10.1039/c7nr09436a
Institutions: University of Kent, Joint Research Centre, Joint Research Centre, Joint Research Centre, Diamond Light Source, University of Bern, University Hospital of Bern, University Children’s Hospital Bern, Institute for Research in Biomedicine, Institute for Research in Biomedicine, Università della Svizzera italiana, German Cancer Research Center, University Medical Center Hamburg-Eppendorf, University Cancer Center Hamburg, Carl von Ossietzky Universität Oldenburg
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2793524385