HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture
Year: 2018
Type: article
Study design: Observational Study
Abstract: ABSTRACT We assessed the additional diagnostic yield for Mycobacterium tuberculosis bloodstream infection (BSI) by doing more than one tuberculosis (TB) blood culture from HIV-infected inpatients. In a retrospective analysis of two cohorts based in Cape Town, South Africa, 72/99 (73%) patients with M. tuberculosis BSI were identified by the first of two blood cultures during the same admission, with 27/99 (27%; 95% confidence interval [CI], 18 to 36%) testing negative on the first culture but positive on the second. In a prospective evaluation of up to 6 blood cultures over 24 h, 9 of 14 (65%) patients with M. tuberculosis BSI had M. tuberculosis grow on their first blood culture; 3 more patients (21%) were identified by a second independent blood culture at the same time point, and the remaining 2 were diagnosed only on the 4th and 6th blood cultures. Additional blood cultures increase the yield for M. tuberculosis BSI, similar to what is reported for nonmycobacterial BSI.
Source: Journal of Clinical Microbiology
DOI: 10.1128/jcm.01914-17
Authors: David A. Barr, Andrew D. Kerkhoff, Charlotte Schutz, Amy M. Ward, Gerry R. Davies, Robert J. Wilkinson, Graeme Meintjes
Institutions: University of Liverpool, University of Cape Town, Wellcome Trust Liverpool Glasgow Centre for Global Health Research, Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of California, San Francisco, University of California San Francisco Medical Center, The Francis Crick Institute, Imperial College London
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,238
Awards: G1460800348, G2006052962, G2301282499, Defining interventions to reduce mortality in severe HIV-associated tuberculosis., Host directed therapies against tuberculosis., G4791776336, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Host directed therapies against tuberculosis., G814105656, G9000204526
OpenAlex ID: W2793528337