Work

POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

Year: 2018

Type: article

Abstract: Significance Here we performed a genetic screen in Drosophila and identified POSH (Plenty of SH3s), an E3 ubiquitin ligase, as a regulator of Hippo pathway. We found POSH ubiquitinates and degrades Ex (Expanded) to inactivate Hippo signaling. Intriguingly, POSH is particularly crucial for damage-induced intestinal stem cell renewal in a Yorki-dependent manner, highlighting the essential physiological role of POSH as a stress sensor in gut epithelia. Given the conservation of the Hippo signaling pathway between Drosophila and human, our findings here suggest that POSH might play a similar role in mammalian growth control.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1715165115

Authors: Xianjue Ma, Xiaowei Guo, Helena E. Richardson, Tian Xu, Lei Xue

Institutions: Tongji University, Howard Hughes Medical Institute, Yale University, La Trobe University, Zhuhai People's Hospital

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Natural Science Foundation of China

Awards: JNK信号通路与Wg信号通路的相互作用及机制研究, JNK与Hippo信号通路在体内的交互作用及机制研究, G6029303095