Work

Anti-Human CD117 Antibodies Mediate Clearance of Myelodysplastic Syndrome Hematopoietic Stem Cells and Facilitate Establishment of Normal Hematopoiesis in Transplantation

Year: 2018

Type: article

Abstract: Myelodysplastic syndrome (MDS) is an aging-associated group of clonal disorders characterized by ineffective hematopoiesis, leading to cytopenias and an increased risk of developing acute myeloid leukemia (AML). MDS arises from abnormal hematopoietic stem cells (HSCs). The only potentially curative therapy available for MDS patients is hematopoietic cell transplantation (HCT), but relapse is common, likely due to the inability of current therapies to effectively eliminate disease-initiating MDS HSCs.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2017.12.211

Authors: Wendy W. Pang, Agnieszka Czechowicz, Jessica Poyser, Christopher Y. Park, Irving L. Weissman, Judith A. Shizuru

Institutions: Stanford Medicine, Stanford University, New York University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650