Work

The effect of posttranslational modifications on biochemical and structural characteristics of Prion Protein variants and the SMN Tudor domain

Year: 2013

Type: dissertation

Abstract: The biochemical consequences of posttranslational modifications of different proteins were analyzed. A C-terminal membrane anchor influenced the biochemical/conformational properties of PrP variants and in vitro evidence for pore formation by one membrane-anchored PrP variant was found. SMN Tudor linked to its low affinity ligand symmetrically dimethylated arginine via different poly-glycine linkers demonstrated that covalent attachment can stabilize such weak interactions.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Nam Chu

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2794055343

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