Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: During the 2014-2015 influenza season in the United States, 256 cases of influenza-associated parotitis were reported from 27 states. We conducted a case-control study and laboratory investigation to further describe this rare clinical manifestation of influenza. Methods: During February 2015-April 2015, we interviewed 50 cases (with parotitis) and 124 ill controls (without parotitis) with laboratory-confirmed influenza; participants resided in 11 states and were matched by age, state, hospital admission status, and specimen collection date. Influenza viruses were characterized using real-time polymerase chain reaction and next-generation sequencing. We compared cases and controls using conditional logistic regression. Specimens from additional reported cases were also analyzed. Results: Cases, 73% of whom were aged <20 years, experienced painful (86%), unilateral (68%) parotitis a median of 4 (range, 0-16) days after onset of systemic or respiratory symptoms. Cases were more likely than controls to be male (76% vs 51%; P = .005). We detected influenza A(H3N2) viruses, genetic group 3C.2a, in 100% (32/32) of case and 92% (105/108) of control specimens sequenced (P = .22). Influenza B and A(H3N2) 3C.3 and 3C.3b genetic group virus infections were detected in specimens from additional cases. Conclusions: Influenza-associated parotitis, as reported here and in prior sporadic case reports, seems to occur primarily with influenza A(H3N2) virus infection. Because of the different clinical and infection control considerations for mumps and influenza virus infections, we recommend clinicians consider influenza in the differential diagnoses among patients with acute parotitis during the influenza season.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciy136
Authors: Melissa A Rolfes, Alexander J Millman, Pamela Talley, Lina I Elbadawi, Natalie A Kramer, John R Barnes, Lenee Blanton, Jeffrey P Davis, Stefanie Cole, John J Dreisig, Rebecca Garten, Thomas Haupt, Mary Anne Jackson, Anna Kocharian, Daniel Leifer, Ruth Lynfield, Karen Martin, Lisa McHugh, Sara Robinson, George Turabelidze, Lori A Webber, Meghan Pearce Weinberg, David E Wentworth, Lyn Finelli, Michael A Jhung
Institutions: Centers for Disease Control and Prevention, Epidemic Intelligence Service, Minnesota Department of Health, Wisconsin Division of Public Health, Michigan Department of Health and Human Services, New Hampshire Department of Health and Human Services, Children's Mercy Hospital, New Jersey Department of Health, State of Maine Department of Health and Human Services, Missouri Department of Health and Senior Services
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Funders: U.S. Department of Health and Human Services, U.S. Department of State, New York State Department of Health, Minnesota Department of Health, Virginia Department of Health, State of New Jersey Department of Health, Missouri Department of Health and Senior Services, Texas Department of State Health Services, National Institutes of Health, Centers for Disease Control and Prevention
Award: G7543494365
OpenAlex ID: W2794448384