Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods: NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Using a standardized questionnaire, we collected demographic and clinical information. Buccal samples were tested at the CDC for selected viruses, including mumps, influenza, human parainfluenza viruses (HPIVs) 1-4, adenoviruses, cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex viruses (HSVs) 1 and 2, and human herpes viruses (HHVs) 6A and 6B. Results: Among the 320 patients, 65% were male, median age was 14.5 years (range, 0-90), and 67% reported unilateral parotitis. Commonly reported symptoms included sore throat (55%) and fever (48%). Viruses were detected in 210 (71%) of 294 NMP patients with adequate samples for testing, ≥2 viruses were detected in 37 samples, and 248 total virus detections were made among all samples. These included 156 influenza A(H3N2), 42 HHV6B, 32 EBV, 8 HPIV2, 2 HPIV3, 3 adenovirus, 4 HSV-1, and 1 HSV-2. Influenza A(H3N2), HHV6B, and EBV were the most frequently codetected viruses. Conclusions: Our findings suggest that, in addition to mumps, clinicians should consider respiratory viral (influenza) and herpes viral etiologies for parotitis, particularly among patients without epidemiologic links to mumps cases or outbreaks.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciy137
Authors: Lina I Elbadawi, Pamela Talley, Melissa A Rolfes, Alexander J Millman, Erik Reisdorf, Natalie A Kramer, John R Barnes, Lenee Blanton, Jaime Christensen, Stefanie Cole, Tonya Danz, John J Dreisig, Rebecca Garten, Thomas Haupt, Beth M Isaac, Mary Anne Jackson, Anna Kocharian, Daniel Leifer, Karen Martin, Lisa McHugh, Rebecca J McNall, Jennifer Palm, Kay W Radford, Sara Robinson, Jennifer B Rosen, Senthilkumar K Sakthivel, Peter Shult, Anna K Strain, George Turabelidze, Lori A Webber, Meghan Pearce Weinberg, David E Wentworth, Brett L Whitaker, Lyn Finelli, Michael A Jhung, Ruth Lynfield, Jeffrey P Davis
Institutions: Centers for Disease Control and Prevention, Epidemic Intelligence Service, Wisconsin Division of Public Health, Minnesota Department of Health, Michigan Department of Health and Human Services, New Hampshire Department of Health and Human Services, New York City Department of Health and Mental Hygiene, Children's Mercy Hospital, New Jersey Department of Health, State of Maine Department of Health and Human Services, Missouri Department of Health and Senior Services
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Health and Human Services, U.S. Department of State, New York State Department of Health, New York City Department of Health and Mental Hygiene, Minnesota Department of Health, Virginia Department of Health, State of New Jersey Department of Health, Missouri Department of Health and Senior Services, Texas Department of State Health Services, National Institutes of Health, Centers for Disease Control and Prevention
Award: G7543494365
OpenAlex ID: W2794709786