Work

Molecular Profiling of Liquid Biopsy Samples for Precision Medicine

Year: 2018

Type: article

Abstract: In the context of oncology, liquid biopsies consist of harvesting cancer biomarkers, such as circulating tumor cells, tumor-derived cell-free DNA, and extracellular vesicles, from bodily fluids. These biomarkers provide a source of clinically actionable molecular information that can enable precision medicine. Herein, we review technologies for the molecular profiling of liquid biopsy markers with special emphasis on the analysis of low abundant markers from mixed populations.

Source: The Cancer Journal

DOI: 10.1097/ppo.0000000000000311

Authors: Camila D.M. Campos, Joshua M. Jackson, Małgorzata A. Witek, Steven A. Soper

Institutions: University of North Carolina at Chapel Hill, University of Kansas, Ulsan National Institute of Science and Technology

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering