A decade of genome-wide association studies for coronary artery disease: the challenges ahead
Year: 2018
Type: review
Abstract: In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 000 people and up to 40 Mio genetic variants. We discuss the challenges ahead, including those involved in identifying causal genes and deciphering the links between risk variants and disease pathology. We also describe novel insights into disease biology based on the findings of genome-wide association studies. Moreover, we discuss the potential for discovery of novel treatment targets through the integration of different layers of 'omics' data and the application of systems genetics approaches. Finally, we provide a brief outlook on the potential for precision medicine to be enhanced by genome-wide association study findings in the cardiovascular field.
Source: Cardiovascular Research
DOI: 10.1093/cvr/cvy084
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,329
Awards: Understanding coronary artery disease genes, G1474772629, G3322091139, AbCD-Net - Analyse des genetischen Risikos für häufige Erkrankungen basierend auf Aberration des Transkriptoms - Genetische Faktoren bei aberrantem Splicing in koronaren Herzerkrankungen (TP 3), G3840481578, G4086240853, G4413410256, G5702163051, G6013935187, G6388590635, Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention
OpenAlex ID: W2795181515