Work

Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS

Year: 2018

Type: article

Abstract: Key Points CUX1 deficiency leads to transient clonal expansion followed by HSC depletion, anemia, and trilineage dysplasia. CUX1 transcriptionally regulates HSC quiescence, proliferation, and lineage specification.

Source: Blood

DOI: 10.1182/blood-2017-10-810028

Authors: Ningfei An, Saira Khan, Molly K. Imgruet, Sandeep K. Gurbuxani, Stephanie N. Konecki, Michael R. Burgess, Megan E. McNerney

Institutions: University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, University of California, San Francisco

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G1828835790, G1945244547, Medical Scientist National Research Service Award, G7995326169, G898378059, Cancer Center Support Grant, Interdisciplinary Training Program in Immunology

OpenAlex ID: W2795300087

FWCI: 4.52

Cites: 65

Cited by: 55

Related to: 10