Work

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides

Year: 2018

Type: article

Abstract: for identification of variants with new biological activities. We also report N-terminal phage display of the class I lanthipeptide nisin and randomization of its A- and B-rings to enrich binders to a small molecule, lipid II. The successful display and randomization of both class I and II lanthipeptides demonstrates the versatility and potential of RiPP display.

Source: ACS Central Science

DOI: 10.1021/acscentsci.7b00581

Authors: Kenton J. Hetrick, Mark C. Walker, Wilfred A. van der Donk

Institutions: Howard Hughes Medical Institute, University of Illinois Urbana-Champaign

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

Funders: National Institutes of Health, University of Illinois at Urbana-Champaign, National Institute of General Medical Sciences, National Center for Research Resources