Year: 2018
Type: article
Study design: Observational Study
Abstract: genital skin LS samples.Thirty-seven percent of male LS USD and 27% of male genital skin LS stained positively for EBV versus none of the female LS samples.LS USD from males expressed significantly higher levels of VEGF compared with female LS (p<0.001) and male skin LS (p<0.01).There was no difference in staining for CD8, Ki67, IgM, Gamma-H2AX, and CCL4.CONCLUSIONS: Immunohistochemistry staining demonstrates differences in the pathophysiology of male genital LS, LS USD, and female genital LS suggesting that they may be distinct disease processes.Our results suggest there may be alteration of cell cycle regulation in LS USD and more significant oxidative stress in male LS.EBV and block-like p16 stains show that there may be an infectious contribution to the formation of male LS.Larger cohorts and further study are needed to elucidate the pathophysiology of genital LS.
Source: The Journal of Urology
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795472086