Mp13-20 the Relationship Between Papillary Grading and Metabolic Risk Factors for Stone Formation
Year: 2018
Type: article
Abstract: 1000 mg calcium, and 30 mg oxalate which was devoid of vitamin C and calcium supplements.The extremely low oxalate diet dramatically limits the contribution of dietary oxalate to the urinary oxalate pool and thus allows an accurate estimation of urinary oxalate derived from endogenous oxalate synthesis.Subjects remained on this diet for 3 days.24hour urine collections were performed on the last two days.Urinary oxalate was measured by ion chromatography coupled with mass spectroscopy.Statistical analysis included Chi-squared, correlation and linear regression analysis, and student t-test.RESULTS: There were 5 subjects in the higher BMI group (3 female and 2 male; mean age 41Æ15 years; mean BMI 36.7Æ4.2) and three in the lower BMI group (2 female, 1 male; age 40Æ7 years; mean BMI 24.7Æ2.7).Subjects in the higher BMI cohort had a significantly greater excretion of urinary oxalate (36Æ7 vs 23Æ5 mg/day, p¼0.021) compared to the lower BMI cohort.Urinary oxalate excretion (mg/day) was positively correlated with waist circumference (r¼0.94,p¼0.0006), waist to hip ratio (r¼0.75, p¼0.03), and BMI (r¼0.9, p¼0.002).CONCLUSIONS: These results demonstrate a positive correlation between urinary oxalate derived from endogenous oxalate synthesis and BMI as well as other measures of obesity.This also provides an explanation for the association between stone risk and obesity.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795530758