Pd09-10 Impaired Sleep Is Associated With Low Testosterone in Us Adult Males: Results From the National Health and Nutrition Survey
Year: 2018
Type: article
Study design: Observational Study
Abstract: INTRODUCTION AND OBJECTIVES: Testosterone deficiency has been linked to several adverse health outcomes -including cardiovascular disease, erectile dysfunction, and metabolic syndrome.Recent data has suggested that abnormal sleep quality may result in lower testosterone levels.Using the 2011-2012 National Health and Nutrition Surveys (NHANES) we assessed the effect of self-reported sleep patterns on serum testosterone while controlling for physical activity levels, co-morbidities, and baseline demographics.METHODS: NHANES is a national cross-sectional survey research program designed to assess the health and nutritional status of adults and children in the United States.Using the 2011-2012 NHANES dataset, we extracted serum total testosterone level, sleep duration, physical activity, demographic and co-morbidities for men aged 16 years and older.Univariate and multivariate linear regression was used to estimate the association of number of hours slept, prior comorbidities, physical activity level and demographics with serum testosterone.RESULTS: Among the 9,756 individuals in the NHANES dataset, 2,672 (27%) were males 16 years and older with a mean patient age of 45.9 who had serum testosterone levels drawn.Mean serum testosterone level was 410.90 ng/dL (2.7 -1795.6 ng/dL).Mean number of hours slept was 6.9 hours (2 -12 hours).On multi-variate logistic regression, we found serum testosterone decreased by 6.376 ng/dL per hour loss of sleep (p ¼ 0.03) and 2.147 ng/dL per unit of body mass index (BMI) increase (p ¼ 1.03 x 10-6 ).Although physical activity and prior co-morbidities such as coronary artery disease, stroke, prior myocardial infarction, and diagnosis of malignancy were associated with serum testosterone on univariate linear regression, they were not found to be statistically significant on multivariate linear regression.CONCLUSIONS: Among men aged 16-80 in the United States, we found low testosterone is associated with impaired sleep and elevated BMI.It is important, therefore, that evaluations of reduced testosterone levels should focus on diet, exercise as well as sleep quality and habits.
Source: The Journal of Urology
Authors: Premal Patel, Taylor Kohn, Ranjith Ramasamy
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795543552