Role of Serum Osteoprotegerin as a Diagnostic Indicator of Primary Osteoporosis in Perimenopausal and Postmenopausal Women: An Indian Perspective
Year: 2018
Type: article
Study design: Observational Study
Abstract: Introduction: Osteoporosis (OP) is a major health problem in the older population.The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a diagnostic indicator of primary osteoporosis in peri-and postmenopausal women in an Indian population.Materials and Methods: After ethical approval, 90 cases (45 cases and 45 controls) of peri-and post-menopausal females above 40 years of age presenting to our outpatient department were included in the study.It was a case controlled study conducted between July 2014 to July 2015.Based on the clinical features, t-score and radiological evidence from the DEXA scan, they were equally divided into two groups (cases and controls).Serum osteoprotegerin (OPG) levels were measured amongst cases and controls.Results: The total calcium (mg/dl) level was lower among the cases and the difference was significant (p-Value= <0.001).Similarly, alkaline phosphatase (u/l), osteoprotegerin (u/ml) levels were higher in the cases as compared to controls and the difference was significant (p-Value= <0.001).The mean osteoprotegerin level showed a slight increase with increase in severity of the grading of BMD of spine.The results suggested a cut-off value of ≥10.5 u/ml (86.7% sensitive and 80% specific with accuracy of 84.5%) between normal and osteoporosis.Conclusion: From the present study, we conclude that osteoprotegerin is a valid biomarker to diagnose postmenopausal women with low bone mineral density.
Source: Malaysian Orthopaedic Journal
DOI: 10.5704/moj.1803.006
Authors: Pandey A, Khan YA, Kushwaha SS, Mohammed F, Verma A
Institution: Era's Lucknow Medical College and Hospital
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $60
OpenAlex ID: W2795570728