Year: 2018
Type: article
Study design: Observational Study
Abstract: You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I1 Apr 2018PD09-01 ADVANCED PATERNAL AGE AFFECTS EMBRYO ANEUPLOIDY IN EGG DONOR CYCLES Robert Carrasquillo, Taylor Kohn, Nasser Al-Asmar Pinar, Carlos Simon, Carmen Rubio, and Ranjith Ramasamy Robert CarrasquilloRobert Carrasquillo More articles by this author , Taylor KohnTaylor Kohn More articles by this author , Nasser Al-Asmar PinarNasser Al-Asmar Pinar More articles by this author , Carlos SimonCarlos Simon More articles by this author , Carmen RubioCarmen Rubio More articles by this author , and Ranjith RamasamyRanjith Ramasamy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.598AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The impact of advanced maternal age on fertility and reproductive outcomes is well-understood, but the influence of advanced paternal age has been less studied and remains controversial. The purpose of this study was to evaluate whether advanced paternal age affects prevalence of embryo aneuploidy in egg donor cycles, as a means of controlling for female partner age. METHODS 1,429 IVF/ICSI cycles (7,683 embryos) with donor eggs, in conjunction with preimplantation genetic testing for aneuploidy (PGT-A), performed between January 2016 and October 2017 were included in this study. All embryos included were biopsied at days 5 and 6 (blastocyst) according to institutional protocol. All of the aneuploidy testing on trophectoderm biopsies was performed using next-generation sequencing. Only cycles with ejaculated sperm were included. Chi-square test was used to assess p-value and statistical significance was set at p < 0.05. RESULTS Results from 7,683 embryos are tabulated in Table 1. Embryo aneuploidy was significantly greater for all men aged > 40 years when compared to men < 34 years (26.7% versus 19.3%, p < 0.001) when using donor eggs. No significant difference in embryo aneuploidy was seen between groups of men aged 40-44, 45-60, and 60+. Despite few patients with available semen analysis data, sperm concentration appears to be similar among men who underwent IVF/ICSI cycles in this cohort. Limitations of this study include lack of outcomes data such as pregnancy and live birth rate, as well as data regarding sperm aneuploidy. CONCLUSIONS To our knowledge, this is the largest study of its kind to evaluate the effect of paternal age on embryo aneuploidy using donor egg cycles. A significant association was found between advancing paternal age and embryo aneuploidy. Further studies are needed to assess whether an increased risk of embryo aneuploidy is associated with negative reproductive outcomes such as decreased live birth rates or congenital anomalies. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e222 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Robert Carrasquillo More articles by this author Taylor Kohn More articles by this author Nasser Al-Asmar Pinar More articles by this author Carlos Simon More articles by this author Carmen Rubio More articles by this author Ranjith Ramasamy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795603320