Mp43-05 S-nitrosoglutathione Reductase (gsnor) Deficiency Is a Novel Model of Secondary Hypogonadism
Year: 2018
Type: article
Abstract: TUNEL, and immunohistochemical analysis for cleaved caspase-3 (apoptosis indicator), -8, -9, SHH and its receptor Patched.RESULTS: Cleaved caspase-3 was present in normal pelvic plexus and increased in a time dependent manner in all nerves of the pelvic plexus when the CN was crushed.Caspase 3 cleaved was identified primarily in glial cells, rather than neurons.Caspase 9 increased in glial cells of all nerves of the pelvic plexus, while very little caspase 8 was observed.SHH was abundant in neurons and glia of the CN, PN, HYG and ANC, while PTCH1 was identified only in neurons.CONCLUSIONS: Interruption of CN innervation, as occurs in the majority of prostatectomy patients, results in induction of apoptosis in other regions of the pelvic plexus, thus affecting continence.Apoptosis occurred primarily through the intrinsic pathway in response to CN injury.Identification of HYG and PN contribution to SUI, and involvement of the SHH pathway, identifies novel treatment avenues for intervention.
Source: The Journal of Urology
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795654013