Mp74-20 the Relationship Between Psa and Total Testosterone Levels in Men With Intermediate and High Grade Prostate Cancer
Year: 2018
Type: article
Study design: Observational Study
Abstract: You have accessJournal of UrologySexual Function/Dysfunction: Evaluation II1 Apr 2018MP74-20 THE RELATIONSHIP BETWEEN PSA AND TOTAL TESTOSTERONE LEVELS IN MEN WITH INTERMEDIATE AND HIGH GRADE PROSTATE CANCER Helen L. Bernie, Bruno Nascimento, Nicole E Benfante, Amy Tin, Sigrid Carlsson, and John P. Mulhall Helen L. BernieHelen L. Bernie More articles by this author , Bruno NascimentoBruno Nascimento More articles by this author , Nicole E BenfanteNicole E Benfante More articles by this author , Amy TinAmy Tin More articles by this author , Sigrid CarlssonSigrid Carlsson More articles by this author , and John P. MulhallJohn P. Mulhall More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2404AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES PSA secretion is a testosterone (T) dependent process. There is published data suggesting that low serum total T level is associated with higher stage, higher grade prostate cancer. However, the link between men diagnosed with intermediate and high-grade prostate cancer (PC), PSA values and T deficiency (TD) has not been explored before. METHODS We included 556 men who underwent RP with a PSA and pre-treatment early morning total T (TT) level; using liquid chromatography-mass spectrometry, measured within 30 days of treatment; and who had Gleason sum ≥7. Univariate logistic regressions were used for the outcomes of TD (T <300 ng/dL) and severe TD (T <200 ng/dL) and predictors included among others, PSA (categories defined as ≤2ng/mL, 2-4 ng/mL, >4 ng/mL) and age. Using locally weighted regressions we evaluated the relationship between PSA and T. RESULTS Median age of our cohort was 62 (IQR 56, 67) years. The distribution by PSA group was: 8% 0-2ng/mL, 14% 2-4ng/mL, 78% >4ng/mL. Median T level across the entire cohort was 368ng/dL (IQR 275, 480), with a median of 380ng/dL and 307ng/dL in patients with Gleason 7 and ≥8 respectively. Overall, 29% had TD; 9% had DM and 49% had HLD. In our cohort, 80% had a Gleason 7, and the remaining had Gleason ≥8. Men with PSA ≤2ng/mL had significantly higher odds of having low, or very low TT compared to men with a PSA level >4 ng/mL. In particular, among all patients, the odd ratios of having TD and severe TD for PSA ≤2ng/mL were 7.3 (95% CI 3.6, 14.8, p<0.0001) and 28 (95% CI 13, 60, p<0.0001).For men with PSA ≤2, TD and severe TD rates were: entire cohort (29%; 10%), G7 (24%; 6%), and G ≥8 (48%; 25%). There was a curvilinear relationship between pre-op PSA and TT levels (Figure), additionally for all values of PSA, TT levels were significantly lower for Gleason ≥8 than for Gleason 7 PC. CONCLUSIONS Low PSA levels predict TD in a cohort of patients with intermediate and high grade PC, with higher rates of TD in higher grade PC. For men diagnosed with prostate cancer with low PSA levels, these data suggest a possible benefit to measuring serum TT also. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1007 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Helen L. Bernie More articles by this author Bruno Nascimento More articles by this author Nicole E Benfante More articles by this author Amy Tin More articles by this author Sigrid Carlsson More articles by this author John P. Mulhall More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795701649