Mp17-05 Correlation Between Single-reader Mri-based Prostate Volume Measurements and Serum Prostate-specific Antigen in Men With Low-risk Prostate Cancer on Active Surveillance
Year: 2018
Type: article
Study design: Observational Study
Abstract: You have accessJournal of UrologyProstate Cancer: Localized: Active Surveillance II1 Apr 2018MP17-05 CORRELATION BETWEEN SINGLE-READER MRI-BASED PROSTATE VOLUME MEASUREMENTS AND SERUM PROSTATE-SPECIFIC ANTIGEN IN MEN WITH LOW-RISK PROSTATE CANCER ON ACTIVE SURVEILLANCE Zachary S. Feuer, Vinay Prabhu, Elton Llukani, Richard Huang, Andrew Rosenkrantz, Xiaosong Meng, James S. Wysock, William C. Huang, Samir Taneja, and Herbert Lepor Zachary S. FeuerZachary S. Feuer More articles by this author , Vinay PrabhuVinay Prabhu More articles by this author , Elton LlukaniElton Llukani More articles by this author , Richard HuangRichard Huang More articles by this author , Andrew RosenkrantzAndrew Rosenkrantz More articles by this author , Xiaosong MengXiaosong Meng More articles by this author , James S. WysockJames S. Wysock More articles by this author , William C. HuangWilliam C. Huang More articles by this author , Samir TanejaSamir Taneja More articles by this author , and Herbert LeporHerbert Lepor More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.560AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A rising PSA on active surveillance (AS) may be interpreted as disease progression. The objective was to characterize time-dependent changes in prostate volume (PV) for men on AS and examine whether these PV changes may account for changes in PSA. METHODS Data were extracted from a prospectively maintained database of 180 men diagnosed with low-risk prostate cancer (PCa) between April 2012 and January 2015 following MRI fusion target biopsy (MRIFB) + systematic biopsy managed with AS. AS follow-up included PSA, DRE, MRI, and surveillance biopsy. 42 of these AS cases without biopsy disease progression underwent repeat serum PSA and MRI between 21 to 36 months. MRI studies were read by a single radiologist, blinded to the original radiology report and order of MRI. MRI-prostate volume MRIPV) was determined using the ellipsoid volume equation. Multivariate logistic regression assessed the correlation between changes in serum PSA and MRIPV, controlling for independent variables. RESULTS Mean (range) PSA and MRIPV at the time of MRIFB were 4.80 ng/mL (0.8-11.7) and 54.39 cm3 (16.46-128.07), respectively. Mean increases in PSA and MRIPV were 0.54 ng/mL, and 5.02 cm3, respectively. No predictive correlation was observed between changes in PSA and MRIPV for the total cohort. Stratifying the cohort into tertiles by the change in MRIPV, there was no significant correlation between changes in serum PSA and MRIPV in the subsets with low (R2=0.013, p=0.69) or intermediate (R2=0.004, p=0.83) changes in MRIPV. However, in those experiencing the greatest change in MRIPV, there was a significant correlation between changes is PSA vs MRIFB (R2=0.440, p=0.01) (Figure 1). CONCLUSIONS In patients on AS experiencing the greatest change in MRIPV, 44% of the variation in PSA was explained by changes in MRIPV. It is reasonable to forego for cause prostate biopsy for men on AS with increasing PSA and MRIPV. Our study suggests that models predicting upgrading of PCa on AS should include changes in MRIPV. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e206-e207 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Zachary S. Feuer More articles by this author Vinay Prabhu More articles by this author Elton Llukani More articles by this author Richard Huang More articles by this author Andrew Rosenkrantz More articles by this author Xiaosong Meng More articles by this author James S. Wysock More articles by this author William C. Huang More articles by this author Samir Taneja More articles by this author Herbert Lepor More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2795724958