Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop
Year: 2018
Type: article
Abstract: Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.
Source: JCI Insight
Authors: Kang Li, Rodosthenis S. Rodosthenous, Fatah Kashanchi, Thomas Gingeras, Stephen J. Gould, Lillian S. Kuo, Peter Kurre, Hakho Lee, Joshua N. Leonard, Huiping Liu, Tania B. Lombo, Stefan Momma, John P. Nolan, Margaret J. Ochocinska, D. Michiel Pegtel, Yoel Sadovsky, Francisco Sánchez-Madrid, Kayla M. Valdes, Kasey C. Vickers, Alissa M. Weaver, Kenneth W. Witwer, Yong Zeng, Saumya Das, Robert L. Raffai, T. Kevin Howcroft
Institutions: San Francisco VA Medical Center, University of California, San Francisco, Massachusetts General Hospital, George Mason University, Cold Spring Harbor Laboratory, Johns Hopkins University, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Oregon Health & Science University, Doernbecher Children's Hospital, Center for Systems Biology, Northwestern University, Chemistry of Life Processes Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Office of the Director, Goethe University Frankfurt, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung, Scintillon Institute, National Heart, Lung, and Blood Institute, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Pittsburgh, Magee-Womens Research Institute, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, National Center for Advancing Translational Sciences, Vanderbilt University Medical Center, Vanderbilt University, University of Kansas, National Cancer Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,100
Awards: G2351413039, HIV neuropathogenesis related to exosomes containing HIV non-coding RNAs, G3220087362, Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine Abuse, G5381554100, G645557210, Integrated Microfluidic Exosome Profiling for Early Detection of Cancer, Macrophage SR-BI Regulates Autophagy, Angiogenin and tRNA-derived small RNAs
OpenAlex ID: W2795741191