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Pd60-04 Defining a Favorable Intermediate-risk Group: Utility of Magnetic Resonance Imaging and Genetic Tests.

Year: 2018

Type: article

Abstract: PSA level (Hazard ratio [HR: 1.01]), pN1 status (HR: 1.63) and grade group 4-5 (HR: 1.79) were associated with CR.The impact of the first PSA level on the risk of CR differed according to nodal status (p<0.001) but not by grade or stage (all p0.1).An increase in the rate of CR at 10-year was observed for pN0 patients with a first PSA >0.25ng/ml.The 10-year CR-free survival were 85.9 vs 76.1% for a first PSA 0.25 vs >0.25ng/ml (p<0.001).In pN1 the risk of CR increased according to the first PSA without a plateau, with a 10year CR-free survival rate of 59%.CONCLUSIONS: The first PSA level after RP should stratify node-negative men where the optimal definition of meaningful PSA persistence associated with 10-year CR was 0.25 ng/ml.These data should be used to tailor the optimal timely salvage therapy in these men.

Source: The Journal of Urology

DOI: 10.1016/j.juro.2018.02.2816

Authors: Ugo Giovanni Falagario, Alp Tuna Beksac, Shivaram Cumarasamy, Paige Xu, Alberto Martini, Akriti Gupta, Kanika Mahajan, Isuru Jayaratna, Ashutosh Tewari

Language: English

Topic: Prostate Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2795904673

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