Work

Mp58-19 a Genomic Classifier for Identifying a Neuroendocrine-like Bladder Cancer Subtype

Year: 2018

Type: article

Abstract: RESULTS: Reproducibility of both classifications was poor.The WHO2004 showed better reproducibility (k¼0.35,95% confidence interval (CI) 0.29-0.42)compared to the WHO1973 as a threetiered (k¼0.24,95% CI 0.19-0.28),but not as a two-tiered (G1þG2 vs G3) classification (k¼0.36,95% CI 0.29-0.42).Reproducibility of individual criteria was poor (k, range: -0.05-0.25).All individual criteria were associated with grade (p<0.05).After a median followup of 60 months, 33/232 and 112/232 patients developed progression and recurrence, respectively.In 3/3 pathologists progression was predicted by the WHO1973-grade in univariable and 1/3 in multivariable analysis.The WHO2004-grade predicted progression in 2/3 and 1/3 pathologists in uni-and multivariable analysis, respectively.Recurrence was not predicted by grade, except for one pathologist (univariable).CONCLUSIONS: Reproducibility of the WHO2004 and the WHO1973 classification for grade are poor.Scoring of individual criteria proved to be poorly reproducible, suggesting that descriptions of these criteria for grade are not specific.Prognostic value of both the WHO1973 and the WHO2004 differ per pathologist.

Source: The Journal of Urology

DOI: 10.1016/j.juro.2018.02.1851

Authors: Yair Lotan, Jonathan Wright, Marc A Dall'Era, Trinity Bivalacqua, Roland Seiler, Yang Liu, Ewan Gibb, Qiqi Wang, Nicholas Erho, Mohammed Alshalalfa, Elai Davicioni, Jason A Efstathiou, James Douglas, Joost L Boormans, Michiel S Van der Heijden, Peter C Black

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2795984555

FWCI:

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