Work

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function

Year: 2018

Type: article

Source: The American Journal of Human Genetics

DOI: 10.1016/j.ajhg.2018.07.016

Authors: Lea M. Starita, Muhtadi M. Islam, Tapahsama Banerjee, Aleksandra I. Adamovich, Justin Gullingsrud, Stanley Fields, Jay Shendure, Jeffrey D. Parvin

Institutions: University of Washington, Brotman Baty Institute, The Ohio State University, Howard Hughes Medical Institute, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, Ohio State University, University of Washington, Pelotonia, National Institutes of Health, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: Comprehensive Biology: Exploiting the Yeast Genome, Interpreting Genetic Variants of Uncertain Significance, Cancer Center Support Grant

OpenAlex ID: W2890179300

FWCI: 11.02

Cites: 37

Cited by: 119

Related to: 10