Work

Tissue-Specific Control of Tissue-Resident Memory T Cells

Year: 2018

Type: article

Abstract: Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of TRMs. Here, we discuss recent advances in the TRM field with a special emphasis on the interaction between local signals and TRMs in the context of individual tissue environment.

Source: Critical Reviews in Immunology

DOI: 10.1615/critrevimmunol.2018025653

Authors: Yong Liu, Chaoyu Ma, Nu Zhang

Institutions: Central South University, The University of Texas at San Antonio Health Science Center, Xiangya Hospital Central South University, Second Xiangya Hospital of Central South University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases